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Extra resources for Annual Review of Immunology Volume 21 2003
Immunol. 21:29-70. org by HINARI on 09/01/07. For personal use only. CD8 T CELL RESPONSES TO PATHOGENS P1: FHD 41 which may prime CD8 T cells while others may only be targets of activated CD8 T cells. Indeed, while epithelial cells and hepatocytes are infected with Listeria, only bone marrow–derived cells are capable of priming na¨ıve cells in vivo (31). Some attempts have been made to measure antigen presentation in vivo (181), but we remain constrained by the limitations of available methods.
Org by HINARI on 09/01/07. For personal use only. CD8 T CELL RESPONSES TO PATHOGENS P1: FHD 47 The complex life cycle of the pathogen involving invasion of two distinct host cells types, one of which lacks MHC class I expression, implies that different arms of the immune system are utilized to combat the distinct life cycle forms of the parasite. Studies using the rodent parasites Plasmodium berghei and Plasmodium yoelli have shown that CD8 T cells are critical for protective immunity specifically against liver stages of infection.
21:29-70. org by HINARI on 09/01/07. For personal use only. SGM LaTeX2e(2002/01/18) P1: FHD PAMER On the other hand, mice lacking 4-1BB ligand (4-1BBL) exhibit normal primary CD8 T cell expansion but decreased numbers of antigen-specific T cells that remain late in the primary response as well as reduced memory responses (68). This suggests that CD28 is critical for initial CD8 expansion during influenza infection, whereas 4-1BBL is needed to maintain T cell numbers later in the response that give rise to the memory pool.